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Potential functions of esophageal cancer-related gene-4 in the cardiovascular system

Rui Zhou, Yuanshu Liu, Wenjun Huang, Xitong Dang

Frontiers of Medicine 2019, Volume 13, Issue 6,   Pages 639-645 doi: 10.1007/s11684-019-0701-0

Abstract: Esophageal cancer-related gene-4 ( ) is cloned from the normal epithelium of the esophagus.during tumorigenesis, and expression levels are inversely correlated with the malignant phenotype of tumorcells, validating that is a real tumor suppressor gene.Unlike other tumor suppressor genes that usually encode membrane or intracellular proteins, encodessuppressor and focus on the emerging roles of Ecrg4 in the CVS.

Keywords： tumor suppressor gene     esophageal cancer-related gene-4     cardiovascular disease     hypoxia    

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ECRG4: a new potential target in precision medicine

Xin Qin, Ping Zhang

Frontiers of Medicine 2019, Volume 13, Issue 5,   Pages 540-546 doi: 10.1007/s11684-018-0637-9

Abstract: Esophageal cancer-related gene-4 ( ), which is initially known as a new candidate tumor suppressor geneECRG4 is unique in its cytokine-like functional pattern and epigenetically-regulated gene expressionThe gene can be released from the cell membrane upon activation and detected in liquid biopsy, thus offering

Keywords： ECRG4     tumor suppressor gene     sentinel molecule     precision medicine     cell senescence     epithelium homeostasis    

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Gene expression disparity in giant cell tumor of bone

Xiaohua PAN, Shuhua YANG, Deming XIAO, Yong DAI, Lili REN

Frontiers of Medicine 2009, Volume 3, Issue 1,   Pages 49-56 doi: 10.1007/s11684-009-0012-y

Abstract: The aim of this paper was to study the differential gene expression of giant cell tumor of bone (GCTB) by gene chip technology.The gene expression disparity between the GCTB samples and normal bony callus was significantly differentSpecific gene spectrum associated with GCTB can be identified by cDNA microarray, which will be the foundation

Keywords： giant cell tumor of bone     gene     microarray     cDNA    

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Paradoxical role of Id proteins in regulating tumorigenic potential of lymphoid cells

Sumedha Roy, Yuan Zhuang

Frontiers of Medicine 2018, Volume 12, Issue 4,   Pages 374-386 doi: 10.1007/s11684-018-0652-x

Abstract: On the contrary, certain Id proteins are reported to act as tumor suppressors in the development of BurkittThe contexts and mechanisms by which Id proteins can serve in such contradictory roles to determine tumorWe re-examine the derailment of these regulatory mechanisms in lymphocytes that facilitate tumor development

Keywords： Id proteins     lymphoma     leukemia     T cells     B cells     tumor suppressor     oncogene    

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662 A/G gene variation in human tumor necrosis factor receptor superfamily, member 9 (TNFRSF9)

QU Yanchun, YANG Ze, SUN Liang, JI Linong

Frontiers of Medicine 2008, Volume 2, Issue 3,   Pages 283-285 doi: 10.1007/s11684-008-0053-7

Abstract: The aim of this paper is to report a new coding variance of the gene, a candidate for autoimmune diseases

Keywords： D-HPLC mutation     development     autoimmune     PCR-RFLP     candidate    

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Antitumor immunity of human SART3 gene vaccine against mouse tumor

HE Yu, YANG Shuhua, LIU Yong, LI Tao

Frontiers of Medicine 2008, Volume 2, Issue 1,   Pages 51-57 doi: 10.1007/s11684-008-0010-5

Abstract: To determine whether squamous cell carcinoma antigen recognized by human T cell 3 (SART3) gene can induceantitumor immunity against tumor cells which express the gene, we constructed mouse tumor cells expressingAfter subcutaneous injection with SART3 gene vaccine, cytotoxic T lymphocyte (CTL) activity was measuredAfter vaccination, tumor occurrence and tumor growth speed was reduced.The vaccine also shows activity in tumor treatment.

Keywords： antitumor therapy     occurrence     implantation     DNA vaccine     SART3 DNA    

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Expression of Syk in non-small cell lung cancer and its relationship with clinicopathological parameters

Fen LAN, Shengdao XIONG, Weining XIONG, Guopeng XU, Xiaoxia LU

Frontiers of Medicine 2009, Volume 3, Issue 1,   Pages 41-44 doi: 10.1007/s11684-009-0009-6

Abstract: The positive rate of Syk was 46.15% (18/39) and 100% (39/39) in NSCLC and tumor-surrounding normal lungThe expression level of Syk in NSCLC was significantly lower than that in tumor-surrounding normal lungno significant association between Syk expression and lymph node metastasis, differentiation degree, tumorsize and tumor node metastasis (TNM).demonstrated that Syk was aberrantly expressed in the NSCLC and might have a significant impact on tumor

Keywords： Syk kinase     carcinoma     non-small-cell lung     tumor suppressor protein p53    

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A systematic survey of LU domain-containing proteins reveals a novel human gene, LY6A, which encodes

Frontiers of Medicine 2023, Volume 17, Issue 3,   Pages 458-475 doi: 10.1007/s11684-022-0968-4

Abstract: study of mouse and human LU domain-containing proteins, we identified a previously unannotated human geneThis gene, hereby named LY6A, reversely overlaps with a lncRNA gene in the majority of exonicCollectively, these studies unveil a novel human gene encoding a candidate biomarker and provide an interestingmodel gene for studying gene regulatory and evolutionary mechanisms.

Keywords： LU domain-containing protein family     novel human gene     LY6A     pituitary tumor     biomarker     nonsynonymous    

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Hepatitis B virus X protein upregulates tumor necrosis factor-α expression of rat mesangial cell

Hong-Zhu LU MD, Dan LIU BM, Qi-Hong FAN BM, Jian-Hua ZHOU MD,

Frontiers of Medicine 2010, Volume 4, Issue 1,   Pages 106-111 doi: 10.1007/s11684-010-0004-y

Abstract: Hepatitis B virus X protein (HBx), a 17-kd protein encoded by X gene of hepatitis B virus (HBV), hasregulated protein kinases (ERKs) pathway of HBx on glomerular mesangial cell (GMC) proliferation and tumorThe HBV X gene was amplified by polymerase chain reaction (PCR), inserted into the eukaryotic expressionPCI-neo containing HBV X gene (pCI-neo-X) was then transfected into cultured GMC line via liposome.

Keywords： hepatitis B virus     X gene     glomerular mesangial cell line     extracellular regulated protein kinases     tumor    

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TNF-alpha secretion from peripheral blood monocular cells by triptolid is associated with TNF-alpha-308 gene

Xiu-Liang TAO MM, Sheng-Hao TU MD, Ri-Bo XIONG MM, Yong-Hong HU BM,

Frontiers of Medicine 2010, Volume 4, Issue 2,   Pages 220-224 doi: 10.1007/s11684-010-0025-6

Abstract: This study examined the inhibitory effect of triptolid (TP) on tumor necrosis factor-α (TNF-αperipheral blood monocular cells (PBMCs) and the association of the inhibitory effect with TNF-α-308 geneGene polymorphism at A-G site 308 in the promoter region of TNF-α gene was detected in 42 It was concluded that gene polymorphism at TNF-α-308 sites may relate to the secretion of TNF-α

Keywords： arthritis     rheumatoid     molonuclear cells     tumor necrosis factor     gene polymorphisms     triptolid    

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Molecular characterization of two suppressor of cytokine signaling 1 genes (

Xue XU,Jiannan ZHANG,Juan LI,Yajun WANG

Frontiers of Agricultural Science and Engineering 2015, Volume 2, Issue 1,   Pages 73-83 doi: 10.15302/J-FASE-2015044

Abstract: Suppressor of cytokine signaling 1 (SOCS1) protein can inhibit the signal transduction triggered by someBesides , a novel gene was also identified in chickens and other non-mammalian vertebrates including

Keywords： chicken     SOCS1a     SOCS1b     growth hormone     prolactin    

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Prospect of Medical Disruptive Technologies

Li Yongjie, Yang Juntao, Du Jian

Strategic Study of CAE 2018, Volume 20, Issue 6,   Pages 64-68 doi: 10.15302/J-SSCAE-2018.06.010

Abstract: This paper mainly analyzes and evaluates five technical directions in tumor immunotherapy, gene editing

Keywords： medical technology     disruptive technology     tumor immunotherapy     gene editing    

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Relative expression of PTTG and bFGF in oral squamous cell carcinoma and Tca8113

Yumei DING BM , Lili CHEN MD , Bo CHENG PhD , Handong ZHANG MM ,

Frontiers of Medicine 2009, Volume 3, Issue 3,   Pages 357-362 doi: 10.1007/s11684-009-0046-1

Abstract: The purpose of this study was to investigate the expression of pituitary tumor transforming gene (PTTG

Keywords： carcinoma     squamous cell     pituitary tumor transforming gene (PTTG) protein     basic fibroblast growth factor    

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Heterogeneity of the tumor immune microenvironment and clinical interventions

Frontiers of Medicine 2023, Volume 17, Issue 4,   Pages 617-648 doi: 10.1007/s11684-023-1015-9

Abstract: Heterogeneity of the tumor immune microenvironment and clinical interventions

Keywords： Heterogeneity tumor immune    

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Recent advances in myeloid-derived suppressor cell biology

Mahmoud Mohammad Yaseen, Nizar Mohammad Abuharfeil, Homa Darmani, Ammar Daoud

Frontiers of Medicine 2021, Volume 15, Issue 2,   Pages 232-251 doi: 10.1007/s11684-020-0797-2

Abstract: In recent years, studying the role of myeloid-derived suppressor cells (MDSCs) in many pathological inflammatory

Keywords： non-human primates (rhesus macaques)     myeloid-derived pro-inflammatory cells (MDPCs)     autoimmune disorders     alloimmune responses     pregnancy     mature MDSCs     multiple sclerosis     Yin-Yang law of MDSCs    

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Title Author Date Type Operation

Potential functions of esophageal cancer-related gene-4 in the cardiovascular system

Rui Zhou, Yuanshu Liu, Wenjun Huang, Xitong Dang

Journal Article

ECRG4: a new potential target in precision medicine

Xin Qin, Ping Zhang

Journal Article

Gene expression disparity in giant cell tumor of bone

Xiaohua PAN, Shuhua YANG, Deming XIAO, Yong DAI, Lili REN

Journal Article

Paradoxical role of Id proteins in regulating tumorigenic potential of lymphoid cells

Sumedha Roy, Yuan Zhuang

Journal Article

662 A/G gene variation in human tumor necrosis factor receptor superfamily, member 9 (TNFRSF9)

QU Yanchun, YANG Ze, SUN Liang, JI Linong

Journal Article

Antitumor immunity of human SART3 gene vaccine against mouse tumor

HE Yu, YANG Shuhua, LIU Yong, LI Tao

Journal Article

Expression of Syk in non-small cell lung cancer and its relationship with clinicopathological parameters

Fen LAN, Shengdao XIONG, Weining XIONG, Guopeng XU, Xiaoxia LU

Journal Article

A systematic survey of LU domain-containing proteins reveals a novel human gene, LY6A, which encodes

Journal Article

Hepatitis B virus X protein upregulates tumor necrosis factor-α expression of rat mesangial cell

Hong-Zhu LU MD, Dan LIU BM, Qi-Hong FAN BM, Jian-Hua ZHOU MD,

Journal Article

TNF-alpha secretion from peripheral blood monocular cells by triptolid is associated with TNF-alpha-308 gene

Xiu-Liang TAO MM, Sheng-Hao TU MD, Ri-Bo XIONG MM, Yong-Hong HU BM,

Journal Article

Molecular characterization of two suppressor of cytokine signaling 1 genes (

Xue XU,Jiannan ZHANG,Juan LI,Yajun WANG

Journal Article

Prospect of Medical Disruptive Technologies

Li Yongjie, Yang Juntao, Du Jian

Journal Article

Relative expression of PTTG and bFGF in oral squamous cell carcinoma and Tca8113

Yumei DING BM , Lili CHEN MD , Bo CHENG PhD , Handong ZHANG MM ,

Journal Article

Heterogeneity of the tumor immune microenvironment and clinical interventions

Journal Article

Recent advances in myeloid-derived suppressor cell biology

Mahmoud Mohammad Yaseen, Nizar Mohammad Abuharfeil, Homa Darmani, Ammar Daoud

Journal Article